Human Calmodulin-Like Protein 5, CALML5 Primacu™ ELISA Kit

Human Calmodulin-Like Protein 5, CALML5 Primacu™ ELISA Kit

• Background: Calmodulin-like protein 5, also known as Calmodulin-like skin protein, CALML5 and CLSP, is a protein which contains fourEF-hand domains. CALML5 / CLSP is particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation.The expression is very low in lung. CALML5 / CLSP binds calcium. It may be involved in terminal differentiation of keratinocytes. Coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin (Ig) superfamily and a component of epithelial tight junction. CAR functions as a primary receptor for coxsackievirus B and adenovirus (Ad) infection. CALML5 / CLSP is closely related to CAR. The structure and dynamics of human calmodulin-like skin protein CALML5 / CLSP have been characterized by NMR spectroscopy. The mobility of CALML5 / CLSP has been found to be different for the N-terminal and C-terminal domains. The N-terminal domain is characterized by four stable helices, which experience large fluctuations. This is shown to be due to mutations in the hydrophobic core. The overall N-terminal domain behavior is similar both in the full-length protein and in the isolated domain.
• Description: Calmodulin-like protein 5
• Synonyms: CLSP
• Gene Name: CALML5
• Gene ID: 51806
• UniProt: Q9NZT1
• Origin Species: Human
• Reactivity: Human
• Target: CALML5
• Field of Research: Cell biology,Signal transduction
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 20 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 31.25-2000 pg/mL
• Sensitivity: 6.2 pg/mL
• Weight: 15893
• Storage Temperature: 2-8°C