Rat Cd59 Glycoprotein, Cd59 Primacu™ ELISA Kit

Rat Cd59 Glycoprotein, Cd59 Primacu™ ELISA Kit

• Background: CD59 glycoprotein, also known as 2 kDa homologous restriction factor, HRF2, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).
• Description: CD59 glycoprotein
• Gene Name: Cd59
• Gene ID: 25407
• UniProt: P27274
• Origin Species: Rat
• Reactivity: Rat
• Target: CD59
• Field of Research: Cardiovascular,Immunology,Signal transduction,Stem cells
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 0.7 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 1.09-70 pg/mL
• Sensitivity: 0.36 pg/mL
• Weight: 13790
• Storage Temperature: 2-8°C