Human Beta-Nerve Growth Factor, NGF Primacu™ ELISA Kit

• Background:

  Nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF protein was identified as a large complex consisting of three non-covalently linked subunits, α, β, and γ, among which, the β subunit, called β-NGF (beta-NGF), was demonstrated to exhibits the growth-stimulating activity of NGF protein. NGFB/beta-NGF gene is a member of the NGF-beta family and encodes a secreted protein that homodimerizes and is incorporated into a larger complex. NGF protein acts via at least two receptors on the surface of cells (TrkA and p75 receptors) to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. Also, previous studies indicated that NGF may also have an important role in the regulation of the immune system.

• Description:

  Beta-nerve growth factor

• Synonyms:

  NGFB

• Gene Name:

  NGF

• Gene ID:

  4803

• UniProt:

  P01138

• Origin Species:

  Human

• Reactivity:

  Human

• Target:

  NGF

• Field of Research:

  Neuroscience

• Assay Type:

  Sandwich

• Assay Performance Time:

  3.5 Hours

• Standard:

  1.4 ng/mL

• Sample Type:

  Serum, plasma, cell culture supernates

• Detection Range:

  2.19-140 pg/mL

• Sensitivity:

  0.92 pg/mL

• Weight:

  26959

• Storage Temperature:

  2-8°C