Human Carboxypeptidase B, CPB1 Primacu™ ELISA Kit

Human Carboxypeptidase B, CPB1 Primacu™ ELISA Kit

• Background: Carboxypeptidase B1, also well known as pancreatic procarboxypeptidase B (PCPB), is a highly pancreas -specific protein (PASP), and has been identified previously as a serum marker for acute pancreatitis and pancreatic graft rejection. As the prototype for those human exopeptidases that cleave off basic C-terminal residues, CPB1 specifically cleaves the C-terminal Arg and Lys residues with a preference for Arg. The B1 and B2 forms of procarboxypeptidase B differ from each other mainly in isoelectric point.The deduced amino acid sequence of PCPB predicts a 416-amino acid preproenzyme consisting of a 15-aa signal peptide, a 95-aa activation peptide and a 37-aa mature chain. The secreted PCPB zymogen is converted to enzymatically active CPB1 by limited proteolysis by trypsin.
• Description: Carboxypeptidase B
• Synonyms: CPB;PCPB
• Gene Name: CPB1
• Gene ID: 1360
• UniProt: P15086
• Origin Species: Human
• Reactivity: Human
• Target: Carboxypeptidase B1
• Field of Research: Metabolism,Signal transduction
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 4 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 6.25-400 pg/mL
• Sensitivity: 1.77 pg/mL
• Weight: 47368
• Storage Temperature: 2-8°C