Human Lymphotoxin-Alpha, LTA Primacu™ ELISA Kit

Human Lymphotoxin-Alpha, LTA Primacu™ ELISA Kit

• Background: Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRSF3 / LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells. TNF-beta/TNFSF1/Lymphotoxin alpha forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNF-beta/TNFSF1/Lymphotoxin alpha is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in TNF-beta/TNFSF1/Lymphotoxin alpha are a cause of susceptibility psoriatic arthritis which is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy.
• Description: Lymphotoxin-alpha
• Synonyms: TNFB;TNFSF1
• Gene Name: LTA
• Gene ID: 4049
• UniProt: P01374
• Origin Species: Human
• Reactivity: Human
• Target: TNF beta
• Field of Research: Neuroscience,Cancer,Immunology,Signal transduction
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 4 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 6.25-400 pg/mL
• Sensitivity: 1.58 pg/mL
• Weight: 22297
• Storage Temperature: 2-8°C