Mouse Intercellular Adhesion Molecule 1, Icam1 Primacu™ ELISA Kit

• Background:

  Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for some immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.

• Description:

  Intercellular adhesion molecule 1

• Synonyms:

  Icam-1

• Gene Name:

  Icam1

• Gene ID:

  15894

• UniProt:

  P13597

• Origin Species:

  Mouse

• Reactivity:

  Mouse

• Target:

  ICAM-1

• Field of Research:

  Neuroscience,Immunology,Microbiology,Cardiovascular,Stem cells

• Assay Type:

  Sandwich

• Assay Performance Time:

  3.5 Hours

• Standard:

  5.6 ng/mL

• Sample Type:

  Serum, plasma, cell culture supernates

• Detection Range:

  8.75-560 pg/mL

• Sensitivity:

  3.03 pg/mL

• Weight:

  58844

• Storage Temperature:

  2-8°C