Mouse Intercellular Adhesion Molecule 1, Icam1 Primacu™ ELISA Kit

Mouse Intercellular Adhesion Molecule 1, Icam1 Primacu™ ELISA Kit

• Background: Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for some immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.
• Description: Intercellular adhesion molecule 1
• Synonyms: Icam-1
• Gene Name: Icam1
• Gene ID: 15894
• UniProt: P13597
• Origin Species: Mouse
• Reactivity: Mouse
• Target: ICAM-1
• Field of Research: Neuroscience,Immunology,Microbiology,Cardiovascular,Stem cells
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 5.6 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 8.75-560 pg/mL
• Sensitivity: 3.03 pg/mL
• Weight: 58844
• Storage Temperature: 2-8°C