Human Granulocyte Colony-Stimulating Factor, CSF3 Primacu™ ELISA Kit

• Background:

  Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial cells. G-CSF binding to its receptor G-CSF-R which belongs to the cytokine receptor type I family depends on the interaction of alpha-helical motifs of the former and two fibronectin type III as well as an immunoglobulin-like domain of the latter. Recent animal studies have also revealed that G-CSF activates multiple signaling pathways, such as Akt and also the Janus family kinase-2 and signal transducer and activation of transcription-3 (Jak2-STAT3) pathway, thereby promoting survival, proliferation, differentiation and mobilisation of haematopoietic stem and progenitor cells. G-CSF is a cytokine that have been demonstrated to improve cardiac function and perfusion in myocardial infarction. And it was initially evaluated as a stem cell mobilizer and erythropoietin as a cytoprotective agent. G-CSF prevents left ventricular remodeling after myocardial infarction by decreasing cardiomyocyte death and by increasing the number of blood vessels, suggesting the importance of direct actions of G-CSF on the myocardium rather than through mobilization and differentiation of stem cells. Accordingly, recombinant human (rh)G-CSF has been extensively used in clinical haematology and oncology to enable bone marrow transplantation or to treat chemotherapy-associated neutropenia. In preclinical study, G-CSF improved cardiac function and perfusion by angiomyogenesis and protection of cardiomyocytes in myocardial infarction. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy

• Description:

  Granulocyte colony-stimulating factor

• Synonyms:

  C17orf33;GCSF

• Gene Name:

  CSF3

• Gene ID:

  1440

• UniProt:

  P09919

• Origin Species:

  Human

• Reactivity:

  Human

• Target:

  G-CSF

• Field of Research:

  Cancer,Immunology,Neuroscience

• Assay Type:

  Sandwich

• Assay Performance Time:

  3.5 Hours

• Standard:

  60 ng/mL

• Sample Type:

  Serum, plasma, cell culture supernates

• Detection Range:

  93.75-6000 pg/mL

• Sensitivity:

  16.98 pg/mL

• Weight:

  22293

• Storage Temperature:

  2-8°C