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(±) -Aiphanol

CAT: 0804-HY-152120Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-152120Size:1 Each
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Description
(±) -Aiphanol is a newly discovered stilbenolignan analog. (±) -Aiphanol exhibits significant anti-inflammatory activity, acting through inhibition of COX-1 and COX-2. The inhibitory effect on COX-1 (IC50 = 1.9 μM) is particularly strong, while the effect on COX-2 (IC50= 9.9 μM) is relatively weak[1]. (±) -Aiphanol effectively inhibits VEGFR2 (IC50=0.92 μM) . (±) -Aiphanol blocks angiogenesis and promotes apoptosis through inhibition of VEGFR2 and COX2 activity. (±) -Aiphanol is orally active[2].
CAS Number
578020-29-8
Product Name Alternative
Aiphanol
UNSPSC
12352005
Target
COX; VEGFR
Type
Natural Products
Related Pathways
Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/racemic-aiphanol.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1[C@@H](C2=CC(OC)=C(C(OC)=C2)O)OC3=CC(/C=C/C4=CC(O)=CC(O)=C4)=CC=C3O1
Molecular Formula
C25H24O8
Molecular Weight
452.45
References & Citations
[1]Kuboki A, et al. Total Synthesis of (.+-.) -Aiphanol, a Novel Cyclooxygenase-inhibitory Stilbenolignan[J]. Chemistry letters, 2003, 32 (5) : 420-421.|[2]Chen S, et al. Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and COX2. Signal Transduct Target Ther. 2021 Dec 3;6 (1) :413.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-1; COX-2; VEGFR2/KDR/Flk-1

Alternative Products

CatalogName
TN7574-01(±) -Aiphanol

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