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Carboplatin

CAT: 0804-HY-17393-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17393-01Size:50 mg
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Description
Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.
CAS Number
41575-94-4
Product Name Alternative
NSC 241240
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H317, H334, H340, H360
Target
Autophagy; DNA Alkylator/Crosslinker; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Carboplatin.html
Purity
99.98
Solubility
H2O : 8.33 mg/mL (ultrasonic)
Smiles
O=C1C2(CCC2)C(O[Pt]O1)=O.N.N
Molecular Formula
C6H12N2O4Pt
Molecular Weight
371.25
Precautions
H302+H312+H332, H317, H334, H340, H360
References & Citations
[1]Natarajan G, et al. Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum (II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Biochem Pharmacol. 1999 Nov 15;58 (10) :1625-9.|[2]Banerji U, et al. An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models. Cancer Chemother Pharmacol. 2008 Oct;62 (5) :769-78.|[3]Clark CC, et al. Enhancement of synthetic lethality via combinations of ABT-888, a PARP inhibitor, and carboplatin in vitro and in vivo using BRCA1 and BRCA2 isogenic models. Mol Cancer Ther. 2012 Sep;11 (9) :1948-58.|[4]Dela Cruz FS, et al. A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. Genome Med. 2016 Oct 31;8 (1) :116.|[5]Hall MD, Telma KA, Chang KE, et al. Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes. Cancer Res. 2014;74 (14) :3913-3922.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched

Chemical Information

Platinum(II),1-cyclobutanedicarboxylato)diammine-, cis-

Carboplatin can cause developmental toxicity according to state or federal government labeling requirements.

CAS Number41575-94-4
PubChem CID426756
IUPAC Nameazanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+)
Molecular FormulaC6H12N2O4Pt
Molecular Weight371.25
Topological Polar Surface Area76.6
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Heavy Atom Count13
Formal Charge0
Complexity177
SMILES
C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
InChI
InChI=1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+2
InChIKey
VSRXQHXAPYXROS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Platinum(II),1-cyclobutanedicarboxylato)diammine-, cis-
CAS: 41575-94-4
CID: 426756
Formula: C6H12N2O4Pt
MW: 371.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight371.25
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Exact Mass371.044501
Monoisotopic Mass371.044501
Topological Polar Surface Area76.6 Ų
Heavy Atom Count13
Formal Charge0
Complexity177
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count4
Compound Is CanonicalizedYes

Alternative Products

CatalogName
1553-100Carboplatin

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