Adarotene

• Description :

  Adarotene is an effective apoptosis inducer, which surprisingly produces DNA damage and exhibites a potent antiproliferative activity on a large panel of human tumor cells.

• Product Name Alternative :

  ST1926

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Adarotene.html

• Purity :

  99.18

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  O=C(O)/C=C/C1=CC=C(C2=CC=C(O)C(C3(C4)CC5CC4CC(C5)C3)=C2)C=C1

• Molecular Formula :

  C25H26O3

• Molecular Weight :

  374.47

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Cincinelli R, et al. A novel atypical retinoid endowed with proapoptotic and antitumor activity. J Med Chem. 2003 Mar 13;46 (6) :909-12.|[2]Garattini E, et al. ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103 (1) :194-207.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [496868-77-0]