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Xanthomicrol

CAT: 0804-HY-W419589-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W419589-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Xanthomicrol is extracted from the resin of the plant called Chinese bellflower (a member of the Scrophulariaceae family) and is a monoamine oxidase (MAOs) inhibitor. Xanthomicrol has anti-tumor and anti-inflammatory properties, with IC50 values of 0.88 and 1.69 μg/mL in HL60 and K562 cells. Xanthomicrol's the main metabolite of 5DT in mouse colon, and it can reduce levels of iNOS protein and mRNA, as well as COX-2 protein levels. Additionally, Xanthomicrol decreases the production of the pro-inflammatory cytokine IL-1β and induces the expression of the antioxidant enzyme HO-1[1][2][3][4][5].
CAS Number
16545-23-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX; Interleukin Related; NO Synthase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/xanthomicrol.html
Purity
97.68
Smiles
COC1=C(OC)C(OC)=C2C(C(C=C(C3=CC=C(O)C=C3)O2)=O)=C1O
Molecular Formula
C18H16O7
Molecular Weight
344.32
Precautions
H302, H315, H319, H335
References & Citations
[1]F. A. TOMAS-BARBERAN, et al. Epicuticular Flavonoids from Beffardia trixago and their Antifungal Fully Methylated Derivatives. Int. J. Crude Drug Res., 28 (l990), No. I, pp. 57-60.|[2]Fereshteh Jahaniani, et al. Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. Phytochemistry. 2005 Jul;66 (13) :1581-92.|[3]Shanshan Guo, et al. Anti-inflammatory effect of xanthomicrol, a major colonic metabolite of 5-demethyltangeretin. Food & Function. 30-Apr-2018.|[4]Fatma Pinar Turkmenoglu, et al. Flavonoids from Sideritis Species: Human Monoamine Oxidase (hMAO) Inhibitory Activities, Molecular Docking Studies and Crystal Structure of Xanthomicrol. Molecules. 2015 Apr 23;20 (5) :7454-73.|[5]Shanshan Guo, et al. Identification of xanthomicrol as a major colonic metabolite of 5-demethyltangeretin in mice and their anti-inflammatory effects in lipopolysaccharide (LPS) -stimulated RAW 264.7 macrophages. Food & Function. 30-Apr-2018.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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