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DPyPE

CAT: 0804-HY-112766-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112766-03Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DPyPE is a neutral phosphatidylethanolamine lipid composed of a polyisoprene alkyl chain with two pyridine-containing phosphine ligands. DPyPE is mainly used in liposome formulations and to enhance the efficiency of gene delivery in vitro and in vivo. For example, DPyPE can be mixed with cationic lipids such as VC1052 (in a 1:1 ratio) to form the vaccine adjuvant Vaxfectin (HY-142998). DPyPE assists VC1052 in binding to negatively charged pDNA to form a uniform liposome complex by regulating the fluidity and stability of the liposome membrane[1][2].
CAS Number
201036-16-0
UNSPSC
12352211
Hazard Statement
H225, H302, H310, H315, H319, H331, H351, H361, H370, H372
Target
Liposome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dpype.html
Purity
98.0
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
NCCOP(OC[C@H](OC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)COC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)(O)=O
Molecular Formula
C45H90NO8P
Molecular Weight
804.17
Precautions
H225, H302, H310, H315, H319, H331, H351, H361, H370, H372
References & Citations
[1]Ferrari ME, et al. Synergy between cationic lipid and co-lipid determines the macroscopic structure and transfection activity of lipoplexes. Nucleic Acids Res. 2002 Apr 15;30 (8) :1808-16.|[2]Hartikka J, et al. Vaxfectin enhances the humoral immune response to plasmid DNA-encoded antigens. Vaccine. 2001 Feb 28;19 (15-16) :1911-23.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

1,2-Diphytanoyl-sn-glycero-3-phosphoethanolamine
CAS Number201036-16-0
PubChem CID9963917
IUPAC Name[(2R)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-(3,7,11,15-tetramethylhexadecanoyloxy)propyl] 3,7,11,15-tetramethylhexadecanoate
Molecular FormulaC45H90NO8P
Molecular Weight804.2
XLogP12.6
Topological Polar Surface Area134
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count39
Heavy Atom Count55
Formal Charge0
Complexity994
SMILES
CC(C)CCCC(C)CCCC(C)CCCC(C)CC(=O)OC[C@H](COP(=O)(O)OCCN)OC(=O)CC(C)CCCC(C)CCCC(C)CCCC(C)C
InChI
InChI=1S/C45H90NO8P/c1-35(2)17-11-19-37(5)21-13-23-39(7)25-15-27-41(9)31-44(47)51-33-43(34-53-55(49,50)52-30-29-46)54-45(48)32-42(10)28-16-26-40(8)24-14-22-38(6)20-12-18-36(3)4/h35-43H,11-34,46H2,1-10H3,(H,49,50)/t37?,38?,39?,40?,41?,42?,43-/m1/s1
InChIKey
XLPHMKQBBCKEFO-DHYROEPTSA-N
Chemical Structure
2D Structure
2D structure of 1,2-Diphytanoyl-sn-glycero-3-phosphoethanolamine
CAS: 201036-16-0
CID: 9963917
Formula: C45H90NO8P
MW: 804.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight804.2
XLogP312.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count39
Exact Mass803.64040583
Monoisotopic Mass803.64040583
Topological Polar Surface Area134 Ų
Heavy Atom Count55
Formal Charge0
Complexity994
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count6
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
GTR19231812-01DPyPE

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