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Eprotirome

CAT: 0804-HY-10473-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10473-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Eprotirome (KB2115) is a liver-selective thyroid hormone receptor (TR) agonist. KB2115 has modestly higher affinity for TRβ than for TRα. Eprotirome reduces low-density lipoprotein (LDL) cholesterol concentrations. Eprotirome can be used for dyslipidemias and obesity research[1][2].
CAS Number
355129-15-6
Product Name Alternative
KB2115
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Eprotirome.html
Purity
99.77
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(O)CC(NC1=CC(Br)=C(OC2=CC=C(O)C(C(C)C)=C2)C(Br)=C1)=O
Molecular Formula
C18H17Br2NO5
Molecular Weight
487.14
Precautions
H302, H315, H319, H335
References & Citations
[1]Martagón AJ, et al. The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob mice. PLoS One. 2015 Apr 7;10 (4) :e0122987.|[2]Rosalba Senese, et al. Thyroid hormone metabolites and analogues. Endocrine. 2019 Oct;66 (1) :105-114.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Alternative Products

CatalogName
319870Eprotirome
A21743-100Eprotirome 100mg
A21743-50Eprotirome 50mg
A21743-25Eprotirome 25mg
A21743-10Eprotirome 10mg
A21743-1Eprotirome 1mg
C15954Eprotirome (KB2115)
A21743-5Eprotirome 5mg
A21743-200Eprotirome 200mg

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