3,7-DMF

• Description:

  3,7-DMF is an orally active inhibitor of TGF-β1-induced activation of HSCs. 3,7-DMF induces antioxidant genes and quenches ROS away, which can be used to study liver fibrosis[1].

• UNSPSC:

  12352005

• Target:

  TGF-beta/Smad

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt; TGF-beta/Smad

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/3-7-dmf.html

• Purity:

  99.79

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic)

• Smiles:

  O=C1C(OC)=C(C2=CC=CC=C2)OC3=C1C=CC(OC)=C3

• Molecular Formula:

  C17H14O4

• Molecular Weight:

  282.29

• References & Citations:

  [1]Hyomin Park , et al. Discovery of 3,7-dimethoxyflavone that inhibits liver fibrosis based on dual mechanisms of antioxidant and inhibitor of activated hepatic stellate cell. Free Radic Biol Med.2023, 204.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [20950-52-1]