2'-Deoxyuridine 5'-monophosphate (disodium)

• UNSPSC Description:

  2'-Deoxyuridine 5'-monophosphate disodium is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis[1].

• Target Antigen:

  Endogenous Metabolite

• Type:

  Oligonucleotides

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/2-deoxyuridine-5-monophosphate-disodium.html

• Purity:

  99.11

• Solubility:

  DMSO : < 1 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : 250 mg/mL (ultrasonic)

• Smiles:

  O[C@H]1C[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O[Na])(O[Na])=O

• Molecular Weight:

  352.15

• References & Citations:

  [1]Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20;45(24):7415-28.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported

• CAS Number:

  42155-08-8