3'-Azido-3'-deoxy-5-methylcytidine

3'-Azido-3'-deoxy-5-methylcytidine

• CAS Number: 1282040-14-5
• UNSPSC Description: 3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC50 of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC50 of 0.06 μM in peripheral blood mononuclear (PBM) cells[1]. 3'-Azido-3'-deoxy-5-methylcytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: HIV; Reverse Transcriptase
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: Neuroscience-Neuromodulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/3_acute_-Azido-3_acute_-deoxy-5-methylcytidine.html
• Purity: 99.90
• Solubility: DMSO : 83.33 mg/mL (ultrasonic)
• Smiles: O[C@@H]1[C@H](N=[N+]=[N-])[C@@H](CO)O[C@H]1N2C=C(C)C(N)=NC2=O
• Molecular Weight: 282.26
• References & Citations: [1]Singh IR, et al. Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. PLoS One. 2010 Apr 1;5(4):e9948.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported