ASP5878

CAT: 0804-HY-19983-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-19983-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

ASP5878 is an oral active inhibitor of FGFR 1, 2, 3, and 4, with IC50 values of 0.47 nM, 0.6 nM, 0.74 nM and 3.5 nM for FGFR 1, 2, 3, and 4 kinase activity. ASP5878 has potential antineoplastic activity[1].

CAS Number

1453208-66-6

UNSPSC

12352005

Target

FGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/asp5878.html

Concentration

10mM

Purity

99.69

Solubility

DMSO : ≥ 250 mg/mL

Smiles

OCCN1N=CC(NC2=NC=C(OCC3=C(F)C(OC)=CC(OC)=C3F)C=N2)=C1

Molecular Formula

C18H19F2N5O4

Molecular Weight

407.37

References & Citations

[1]Futami T, et al. ASP5878, a Novel Inhibitor of FGFR1, 2, 3, and 4, Inhibits the Growth of FGF19-Expressing Hepatocellular Carcinoma. Mol Cancer Ther. 2017 Jan;16 (1) :68-75.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

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ASP5878

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