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TRV-120027 TFA

CAT: 0013-GTR18918657-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18918657-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRV-120027 TFA is a β-arrestin-biased AT1R agonist that selectively inhibits angiotensin II-mediated G-protein signaling while promoting β-arrestin-1 recruitment. This action inhibits vasoconstriction, enhances cardiomyocyte contractility, and triggers catecholamine secretion via a macromolecular AT1R–β-arrestin-1–TRPC3–PLCγ complex. It is a valuable research tool for studying biased GPCR signaling in cardiovascular physiology and disease models.
Product Name Alternative
1234510-46-3, 1234510-46-3 free base, AT1 receptor, the angiotensin II receptor type 1, TRP Channel, TRPChannel, TRPV Channel, TRPVChannel, TRV 120027 TFA, TRV120027 TFA, TRV-120027 TFA, TRV-120027 TFA (1234510-46-3 free base)
Field of Research
Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery
Purity
97.45% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (3.17 mM) ; DMSO:88 mg/mL (84.61 mM)
Molecular Weight
1040.1
Storage Conditions
Keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

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