RB-3

• Description :

  RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM[1].

• UNSPSC :

  12352005

• Target :

  E1/E2/E3 Enzyme

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/rb-3.html

• Purity :

  99.42

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(C2=C3C=CNC3=CC=C2Cl)C(C(C)C)=C(C4=C5C=CNC5=CC=C4)N1)O

• Molecular Formula :

  C24H20ClN3O2

• Molecular Weight :

  417.89

• References & Citations :

  [1]Shirish Shukla, et al. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat Chem Biol. 2021 Jul;17 (7) :784-793.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2396639-11-3]