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Tosatoxumab

CAT: 0804-HY-P99551-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99551-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes alpha-toxin (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent. Recommend Isotope Control: Human IgG1 lambda1, Isotype Control[2].
CAS Number
1374419-41-6
Product Name Alternative
KBSA301; AR-301
UNSPSC
12352203
Target
Antibiotic; Bacterial
Type
Inhibitory Antibodies
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/tosatoxumab.html
Purity
95.00
Solubility
H2O
Smiles
[Tosatoxumab]
Molecular Weight
(144.92 kDa)
References & Citations
[1]Bruno François, et al. Safety and tolerability of a single administration of AR-301, a human monoclonal antibody, in ICU patients with severe pneumonia caused by Staphylococcus aureus: first-in-human trial. Intensive Care Med. 2018 Nov;44 (11) :1787-1796.|[2]Philippe Vignon, et al. New Agents in Development for Sepsis: Any Reason for Hope? Drugs. 2020 Nov;80 (17) :1751-1761.|[3]Lugovskoy, A. A., et al., (2012) . 7th annual European Antibody Congress 2011: November 29-December 1, 2011, Geneva, Switzerland. mAbs, 4 (2), 134–152.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3

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