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Pomstafib-2

CAT: 0804-HY-112649-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112649-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pomstafib-2 is a potent and selective STAT5b inhibitor. Pomstafib-2 decreases the expression of pSTAT5b and induces Apoptosis[1][2].
CAS Number
2332841-83-3
UNSPSC
12352005
Target
Apoptosis; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomstafib-2.html
Purity
99.37
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CC=C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)=C1)COC2=CC=C(C(NC3=CC=C(OC4=CC=CC=C4)C=C3)=O)C=C2
Molecular Formula
C52H66N2O20P2
Molecular Weight
1101.03
References & Citations
[1]Elumalai N, et al. Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b. Sci Rep. 2017 Apr 11;7 (1) :819.|[2]Gräb J, et al. The STAT5b Linker Domain Mediates the Selectivity of Catechol Bisphosphates for STAT5b over STAT5a. ACS Chem Biol. 2019 Apr 19;14 (4) :796-805.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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