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Mapatumumab

CAT: 0804-HY-P99265-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99265-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mapatumumab (HGS-ETR1) is a fully human IgG1 agonistic monoclonal antibody that targets tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) . Mapatumumab can be used for the research of cancer[1].
CAS Number
658052-09-6
Product Name Alternative
HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody
UNSPSC
12352203
Target
Others
Type
Inhibitory Antibodies
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mapatumumab.html
Purity
97.85
Solubility
10 mM in DMSO
Smiles
[Mapatumumab]
Molecular Weight
(143.52 kDa)
References & Citations
[1]Smith MA, et al. Initial testing (stage 1) of mapatumumab (HGS-ETR1) by the pediatric preclinical testing program. Pediatr Blood Cancer. 2010 Feb;54 (2) :307-10.|[2]Ahmed SM, et al. Synergistic induction of apoptosis by mapatumumab and anthracyclines in human bladder cancer cells. Oncol Rep. 2015 Feb;33 (2) :566-72.|[3]Marini P, et al. Combination of the pro-apoptotic TRAIL-receptor antibody mapatumumab with ionizing radiation strongly increases long-term tumor control under ambient and hypoxic conditions. Int J Radiat Oncol Biol Phys. 2009 Sep 1;75 (1) :198-202.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2

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