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Trilexium

CAT: 0804-HY-157800-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-157800-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Trilexium (TRX-E-009-1) is a third-generation of benzopyran structurally related to TRX-E-002-1. Trilexium increases p21 protein expression and induces apoptosis. Trilexium depolymerizes microtubules. Trilexium shows broad anti-cancer activity[1][2].
CAS Number
1983180-82-0
Product Name Alternative
TRX-E-009-1
UNSPSC
12352005
Target
Apoptosis; Caspase; Microtubule/Tubulin; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trilexium.html
Purity
99.70
Solubility
DMSO : 300 mg/mL (ultrasonic)
Smiles
OC1=C(OC)C=C([C@H]2[C@@H](C3=CC(F)=C(C=C3)O)C4=CC=C(O)C(C)=C4OC2)C=C1OC
Molecular Formula
C24H23FO6
Molecular Weight
426.43
References & Citations
[1]Stevenson AJ, et al. Mechanism of action of the third generation benzopyrans and evaluation of their broad anti-cancer activity in vitro and in vivo. Sci Rep. 2018 Mar 23;8 (1) :5144. |[2]Ehteda A, et al. Microtubule-Targeting Combined with HDAC Inhibition Is a Novel Therapeutic Strategy for Diffuse Intrinsic Pontine Gliomas. Mol Cancer Ther. 2023 Dec 1;22 (12) :1413-1421.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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