Etonogestrel

CAT: 0804-HY-B0652-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0652-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs[1]. Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) [2].
CAS Number
[54048-10-1]
Product Name Alternative
3-Oxodesogestrel; 3-keto-Desogestrel
UNSPSC
12352211
Hazard Statement
H351, H360
Target
Drug Metabolite; Endogenous Metabolite; Estrogen Receptor/ERR; FKBP; Progesterone Receptor
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/Etonogestrel.html
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC[C@]([C@]1(O)C#C)(C2)[C@](CC1)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@@]3([H])CC4)([H])C2=C
Molecular Formula
C22H28O2
Molecular Weight
324.46
Precautions
H351, H360
References & Citations
[1]http://www.drugbank.ca/drugs/DB00294|[2]Dionne D. Maddox, et al. Etonogestrel (Implanon), Another Treatment Option for Contraception. P T. 2008 Jun; 33 (6) : 337–347.|[3]Ozlem Guzeloglu Kayisli, et al. Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive- Associated Abnormal Uterine Bleeding. PLoS One. 2015 Oct 5;10 (10) :e0137855.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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