Ampreloxetine

• Description :

  Ampreloxetine (TD-9855) is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine has the potential for the research of neurogenic orthostatic hypotension[1][2].

• CAS Number :

  [1227056-84-9]

• Product Name Alternative :

  TD-9855

• UNSPSC :

  12352005

• Target :

  5-HT Receptor; Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ampreloxetine.html

• Purity :

  98.49

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  FC1=C(OCC2=CC=CC=C2C3CCNCC3)C(F)=CC(F)=C1

• Molecular Formula :

  C18H18F3NO

• Molecular Weight :

  321.34

• References & Citations :

  [1]Smith JA, et al. Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor. Int J Neuropsychopharmacol. 2014 Dec 13;18 (2) :pyu027. |[2]Kaufmann H, et al. Safety and efficacy of ampreloxetine in symptomatic neurogenic orthostatic hypotension: a phase 2 trial. Clin Auton Res. 2021 Dec;31 (6) :699-711.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• Isoform :

  MUC4