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Psoralidin

CAT: 0804-HY-N0232-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0232-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR) -induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties[1]. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation[2].
CAS Number
18642-23-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; COX; Lipoxygenase; Notch; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Psoralidin.html
Purity
99.90
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C/C(C)=C\CC1=C(C=C2OC(C3=C(C2=C1)OC4=C3C=CC(O)=C4)=O)O
Molecular Formula
C20H16O5
Molecular Weight
336.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Yang HJ, et al. Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR) -induced pulmonary inflammation.Biochem Pharmacol. 2011 Sep 1;82 (5) :524-34.|[2]Suman S, et al. Silencing NOTCH signaling causes growth arrest in both breast cancer stem cells and breast cancer cells.Br J Cancer. 2013 Nov 12;109 (10) :2587-96.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
5-LOX; COX-2

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