Trifloxystrobin

• Description :

  Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases[1][2][3][4][5].

• Product Name Alternative :

  CGA 279202

• UNSPSC :

  12352005

• Hazard Statement :

  H317, H410

• Target :

  Apoptosis; Caspase; Fungal; PARP

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Trifloxystrobin.html

• Purity :

  99.68

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C/C(C1=CC(C(F)(F)F)=CC=C1)=N\OCC2=C(C=CC=C2)/C(C(OC)=O)=N\OC

• Molecular Formula :

  C20H19F3N2O4

• Molecular Weight :

  408.37

• Precautions :

  H317, H410

• References & Citations :

  [1]Jang Y, et al. Trifloxystrobin induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) -mediated apoptosis in HaCaT, human keratinocyte cells [J]. Drug and Chemical Toxicology, 2017, 40 (1) : 67-73.|[2]Nguyen K, et al. Neurotoxicity assessment of QoI strobilurin fungicides azoxystrobin and trifloxystrobin in human SH-SY5Y neuroblastoma cells: Insights from lipidomics and mitochondrial bioenergetics[J]. Neurotoxicology, 2022, 91: 290-304.|[3]Li H, et al. Developmental toxicity, oxidative stress and immunotoxicity induced by three strobilurins (pyraclostrobin, trifloxystrobin and picoxystrobin) in zebrafish embryos [J]. Chemosphere, 2018, 207: 781-790.|[4]Wu R, et al. Oxidative stress and DNA damage induced by trifloxystrobin on earthworms (Eisenia fetida) in two soils [J]. Science of The Total Environment, 2021, 797: 149004.|[5]Villares M, et al. Trifloxystrobin blocks the growth of Theileria parasites and is a promising drug to treat Buparvaquone resistance [J]. Communications Biology, 2022, 5 (1) : 1253.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Caspase 3; Caspase 8; Caspase 9

• CAS Number :

  [141517-21-7]