Nebidrazine

CAT: 0804-HY-155297Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-155297Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Nebidrazine is a centrally-acting hypotensive agent compared to clonidine, demonstrating weaker cardiovascular effects in rats. It induces dose-dependent hypotension and bradycardia when administered intracerebroventricularly (i.c.v.), with significantly lower sedative potential than clonidine in conscious rats. Yohimbine attenuates the cardiovascular effects of both Nebidrazine and clonidine, suggesting involvement of central alpha-autoreceptors sensitive to yohimbine. Unlike clonidine, Nebidrazine does not affect peripheral alpha-adrenoceptors in pithed rats, indicating a selective central mechanism. Chemical sympathectomy reduces Nebidrazine's cardiovascular effects more than clonidine's, and metiamide diminishes responses to both drugs, implicating central histamine receptors. These findings highlight Nebidrazine's distinct pharmacological profile and potential therapeutic application in managing hypertension through central alpha-autoreceptor stimulation[1].

CAS Number

55248-23-2

Product Name Alternative

FLA-136

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nebidrazine.html

Smiles

ClC1=CC=CC(Cl)=C1/C=N/NC2=NN=CN2N

Molecular Formula

C9H8Cl2N6

Molecular Weight

271.11

References & Citations

[1]A COMPARISON OF THE CARDIOVASCULAR AND SEDATIVE ACTIONS OF THE x-ADRENOCEPTOR AGONISTS, FLA-136 AND CLONIDINE, IN THE RAT

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Alternative Products

Catalog	Name
GTR19210819-01	Nebidrazine

Nebidrazine

Alternative Products

Popular Products