4′-Demethylnobiletin
CAT:
804-HY-142066-03
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
4′-Demethylnobiletin
- CAS Number: 34810-62-3
- UNSPSC Description: 4′-Demethylnobiletin is a bioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signaling[1].
- Target Antigen: ERK; iGluR; PKA
- Type: Reference compound
- Related Pathways: MAPK/ERK Pathway;Membrane Transporter/Ion Channel;Neuronal Signaling;Stem Cell/Wnt;TGF-beta/Smad
- Applications: Neuroscience-Neurodegeneration
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/4-demethylnobiletin.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C1C=C(C2=CC=C(O)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(OC)=C13
- Molecular Weight: 388.37
- References & Citations: [1]Md Al Rahim, et al. 4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade. Biochemistry. 2009 Aug 18;48(32):7713-21.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported