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MYX1715

CAT: 0804-HY-164285-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164285-01Size:1 mg
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Description
MYX1715 is an inhibitor of N-Myristoyltransferase (NMT) with a KD value of 0.09 nM. MYX1715 inhibits the proliferation of LU0884 and LU2511 with IC50 values of 44 nM and 9 nM. MYX1715 exhibits antitumor efficacy against neuroblastoma and gastric cancer in mouse models. MYX1715 can be used as ADC toxin[1][2].
CAS Number
2445448-66-6
UNSPSC
12352005
Target
ADC Payload; N-myristoyltransferase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/myx1715.html
Concentration
10mM
Purity
99.55
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N(C)C)C1=NN(C)C(C)=C1CCOC2=C(C3=CN4C(CCN)=CN=C4C=C3)C=CC(Cl)=C2
Molecular Formula
C25H29ClN6O2
Molecular Weight
480.99
References & Citations
[1]Zhang J, et al. Dysregulation of MYC-Family Proteins Sensitises Cancers to NMT Inhibition: Identification of NMTi Sensitivity and Mechanism[J]. Cancer Research, 2023, 83 (7_Supplement) : 4871-4871.|[2]Carr R, et al. N-Myristoyltransferase (NMT) inhibitors are completely novel payloads for Antibody Drug Conjugates that deliver extensive tumor regression at well tolerated doses[J].
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

4-(2-(2-(3-(2-aminoethyl)imidazo[1,2-a]pyridin-6-yl)-5-chlorophenoxy)ethyl)-N,N,1,5-tetramethyl-1H-pyrazole-3-carboxamide
CAS Number2445448-66-6
PubChem CID146971285
IUPAC Name4-[2-[2-[3-(2-aminoethyl)imidazo[1,2-a]pyridin-6-yl]-5-chlorophenoxy]ethyl]-N,N,1,5-tetramethylpyrazole-3-carboxamide
Molecular FormulaC25H29ClN6O2
Molecular Weight481.0
XLogP3.8
Topological Polar Surface Area90.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count34
Formal Charge0
Complexity684
SMILES
CC1=C(C(=NN1C)C(=O)N(C)C)CCOC2=C(C=CC(=C2)Cl)C3=CN4C(=NC=C4CCN)C=C3
InChI
InChI=1S/C25H29ClN6O2/c1-16-20(24(29-31(16)4)25(33)30(2)3)10-12-34-22-13-18(26)6-7-21(22)17-5-8-23-28-14-19(9-11-27)32(23)15-17/h5-8,13-15H,9-12,27H2,1-4H3
InChIKey
AMLXJNZNGSKREP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(2-(2-(3-(2-aminoethyl)imidazo[1,2-a]pyridin-6-yl)-5-chlorophenoxy)ethyl)-N,N,1,5-tetramethyl-1H-pyrazole-3-carboxamide
CAS: 2445448-66-6
CID: 146971285
Formula: C25H29ClN6O2
MW: 481.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight481.0
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass480.2040519
Monoisotopic Mass480.2040519
Topological Polar Surface Area90.7 Ų
Heavy Atom Count34
Formal Charge0
Complexity684
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
T88528-01MYX1715

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