Hexetidine

• Description :

  Hexetidine (NSC-17764) is an orally active antibacterial and antifungal agent with broad antibacterial and antifungal activity. Hexetidine combined with IPBC potentiates strong fungal growth inhibition properties. Hexetidine at concentrations greater than 0.1% can cause oral ulceration. Additionally, Hexetidine improves its plaque inhibiting activities combined with zinc and has been confirmed the effectiveness on purulent wound along with ultrasound. Hexetidine is a promising candidate for research in fungus-related diseases and soft tissue purulent-inflammatory[1][2][3][4][5]

• CAS Number :

  [141-94-6]

• Product Name Alternative :

  NSC-17764

• UNSPSC :

  12352005

• Hazard Statement :

  H227, H315, H319, H335

• Target :

  Bacterial; Fungal

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/Hexetidine.html

• Purity :

  98.0

• Solubility :

  DMSO : 200 mg/mL (ultrasonic; warming; heat to 80°C) |Ethanol : 100 mg/mL (ultrasonic)

• Smiles :

  NC1(C)CN(CC(CC)CCCC)CN(CC(CC)CCCC)C1

• Molecular Formula :

  C21H45N3

• Molecular Weight :

  339.60

• Precautions :

  H227, H315, H319, H335

• References & Citations :

  [1]Afennich F, et al. The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review.Int J Dent Hyg. 2011 Aug;9 (3) :182-90.|[2]Vallières C, et al. Potentiated inhibition of Trichoderma virens and other environmental fungi by new biocide combinations[J]. Appl Microbiol Biotechnol. 2021 Apr;105 (7) :2867-2875.|[3]Dr. Sandhya Gnanasambandam, et al. Role of supra-gingival plaque in the pathophysiology of periodontitis. World Journal of Pharmaceutical Research. 2024 April 12; 13 (8) : 902-915.|[4]Ivan S. Dragovoz, et al. Comparative Evaluation of Isolated and Complex Use of Hexetidine and Photoditazine in Combination with Ultrasound Therapy in the Treatment of Purulent Wounds under Experimental Conditions[J]. International Journal of Biomedicine. 2022 March 20; 12 (1) :138-141|[5]Gorman SP, et al. The concomitant development of poly (vinyl chloride) -related biofilm and antimicrobial resistance in relation to ventilator-associated pneumonia[J]. Biomaterials. 2001 Oct;22 (20) :2741-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 4