Hexetidine

CAT: 0804-HY-B0996-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0996-01Size:25 mg
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Description
Hexetidine (NSC-17764) is an orally active antibacterial and antifungal agent with broad antibacterial and antifungal activity. Hexetidine combined with IPBC potentiates strong fungal growth inhibition properties. Hexetidine at concentrations greater than 0.1% can cause oral ulceration. Additionally, Hexetidine improves its plaque inhibiting activities combined with zinc and has been confirmed the effectiveness on purulent wound along with ultrasound. Hexetidine is a promising candidate for research in fungus-related diseases and soft tissue purulent-inflammatory[1][2][3][4][5]
CAS Number
[141-94-6]
Product Name Alternative
NSC-17764
UNSPSC
12352005
Hazard Statement
H227, H315, H319, H335
Target
Bacterial; Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Hexetidine.html
Purity
98.0
Solubility
DMSO : 200 mg/mL (ultrasonic; warming; heat to 80°C) |Ethanol : 100 mg/mL (ultrasonic)
Smiles
NC1(C)CN(CC(CC)CCCC)CN(CC(CC)CCCC)C1
Molecular Formula
C21H45N3
Molecular Weight
339.60
Precautions
H227, H315, H319, H335
References & Citations
[1]Afennich F, et al. The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review.Int J Dent Hyg. 2011 Aug;9 (3) :182-90.|[2]Vallières C, et al. Potentiated inhibition of Trichoderma virens and other environmental fungi by new biocide combinations[J]. Appl Microbiol Biotechnol. 2021 Apr;105 (7) :2867-2875.|[3]Dr. Sandhya Gnanasambandam, et al. Role of supra-gingival plaque in the pathophysiology of periodontitis. World Journal of Pharmaceutical Research. 2024 April 12; 13 (8) : 902-915.|[4]Ivan S. Dragovoz, et al. Comparative Evaluation of Isolated and Complex Use of Hexetidine and Photoditazine in Combination with Ultrasound Therapy in the Treatment of Purulent Wounds under Experimental Conditions[J]. International Journal of Biomedicine. 2022 March 20; 12 (1) :138-141|[5]Gorman SP, et al. The concomitant development of poly (vinyl chloride) -related biofilm and antimicrobial resistance in relation to ventilator-associated pneumonia[J]. Biomaterials. 2001 Oct;22 (20) :2741-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4

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