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MC1742

CAT: 0804-HY-110280-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110280-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MC1742 is a potent HDAC inhibitor, with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC[1].
CAS Number
1776116-74-5
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc1742.html
Purity
98.95
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C1N=C(NC(C2=CC=C(C3=CC=CC=C3)C=C2)=C1)SCCCCC(NO)=O
Molecular Formula
C21H21N3O3S
Molecular Weight
395.47
References & Citations
[1]Di Pompo G, et al. Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. J Med Chem. 2015;58 (9) :4073-4079.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC6; HDAC8

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