Sitagliptin

• UNSPSC Description:

  Sitagliptin (MK-0431) is a potent and orally active inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts[1].

• Target Antigen:

  Autophagy; Dipeptidyl Peptidase

• Type:

  Reference compound

• Related Pathways:

  Autophagy;Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Sitagliptin.html

• Smiles:

  O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F

• Molecular Weight:

  407.31

• References & Citations:

  [1]Thomas, L., et al. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. J Pharmacol Exp Ther. 2008 Apr;325(1):175-82.|[2]Kim, S.J., et al., Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Diabetes, 2009. 58(3): p. 641-51.|[3]Sangle, G.V., et al., Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a GLP-1 secretagogue. Endocrinology, 2012. 153(2): p. 564-73.|[4]Kim, S.J., et al., Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice. Diabetes, 2008. 57(5): p. 1331-9.|[5]Beconi, M.G., et al. Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs. Drug Metab Dispos, 2007. 35(4): p. 525-32.Biochem Pharmacol. 2023 Oct 5:115846.|Biochim Biophys Acta Mol Basis Dis. 2024 Jul 25:167433.|Cell Death Dis. 2021 Oct 11;12(10):928.|Exp Cell Res. 2024 Sep 12;442(2):114254.|Front Oncol. 24 September 2021.|iScience. 2023 Feb.|J Adv Res. 2024 Oct 5:S2090-1232(24)00433-8.|J Biol Chem. 2018 Dec 7;293(49):18864-18878. |J Nanobiotechnology. 2024 Oct 16;22(1):631.|J Sep Sci. 2021 Oct 28.|Korean J Physiol Pharmacol. 2021 Sep 1;25(5):425-437.|Neurol Res. 2018 Sep;40(9):736-743.|Nutr Neurosci. 2018 Apr 26:1-17.|Nutrition. 2024 Aug 29.|Orebro University. 2024.|Oxid Med Cell Longev. 2019 Nov 15;2019:6181754.|Oxid Med Cell Longev. 2022 May 17;2022:2586305.|Research Square Preprint. 2024 Apr 25.|Sci Rep. 2019 Mar 11;9(1):4074.|Biomed Pharmacother. 2023 Mar 24;162:114555.|bioRxiv. 2023 Nov 4.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  486460-32-6