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β-Anhydroicaritin

CAT: 0804-HY-N1940-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1940-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties[1]. β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats[2]. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca2+, and markedly decreases iNOS protein expression[3].
CAS Number
38226-86-7
Product Name Alternative
Cycloicaritin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Interleukin Related; MMP; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/beta-anhydroicaritin.html
Purity
99.69
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
O=C1C2=C(O)C=C3C(CCC(C)(C)O3)=C2OC(C4=CC=C(OC)C=C4)=C1O
Molecular Formula
C21H20O6
Molecular Weight
368.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Nguyen VS, et al. Synthesis of Icaritin and β-anhydroicaritin Mannich Base Derivatives and Their Cytotoxic Activities on Three Human Cancer Cell Lines. Anticancer Agents Med Chem. 2017;17 (1) :137-142|[2]Wu Y, et al. Effect of β-anhydroicaritin on the expression levels of tumor necrosis factor-α and matrix metalloproteinase-3 in periodontal tissue of diabetic rats. Mol Med Rep. 2015 Aug;12 (2) :1829-37.|[3]Lai X, et al. Protective effect of anhydroicaritin against peritonitis in mice. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Oct;29 (10) :1036-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
IL-10; IL-6; MMP-3; TNFRSF5/CD40

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