Lanepitant

• Description:

  Lanepitant (LY303870) is a selective neurokinin-1 (NK-1) receptor antagonist. Lanepitant blocks neurogenic inflammation and pain transmission by preventing the binding of substance P to NK-1 receptors on both neuronal and non-neuronal tissues. Lanepitant can be used to study osteoarthritis[1].

• Product Name Alternative:

  LY303870

• UNSPSC:

  12352005

• Target:

  Neurokinin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/lanepitant.html

• Smiles:

  O=C(N[C@H](CC1=CNC2=C1C=CC=C2)CN(C(C)=O)CC3=CC=CC=C3OC)CN4CCC(N5CCCCC5)CC4

• Molecular Formula:

  C33H45N5O3

• Molecular Weight:

  559.74

• References & Citations:

  [1]Goldstein D J, et al. Study of the analgesic effect of lanepitant in patients with osteoarthritis pain[J]. Clinical Pharmacology & Therapeutics, 2000, 67 (4) : 419-426.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [170566-84-4]