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Tiagabine

CAT: 0804-HY-B0696-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0696-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tiagabine (NO050328) is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively[1].
CAS Number
115103-54-3
Product Name Alternative
NO050328; NO328; TGB
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tiagabine.html
Purity
98.49
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1CN(CC/C=C(C2=C(C)C=CS2)/C3=C(C)C=CS3)CCC1)O
Molecular Formula
C20H25NO2S2
Molecular Weight
375.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Braestrup C, et al. (R) -N-[4,4-bis (3-methyl-2-thienyl) but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier. J Neurochem. 1990 Feb;54 (2) :639-47.|[2]Sheehan, D.V., et al., An open-label study of tiagabine in panic disorder. Psychopharmacol Bull, 2007. 40 (3) : p. 32-40.|[3]Henjum, S. and B. Hassel, High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study. Neurochem Int, 2007. 50 (2) : p. 365-70.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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