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Ilorasertib

CAT: 0804-HY-16018-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16018-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ilorasertib (ABT-348) is a potent, orally active and ATP-competitive aurora inhibitor with IC50s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib also is a potent VEGF, PDGF inhibitor. Ilorasertib has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) [1][2].
CAS Number
1227939-82-3
Product Name Alternative
ABT-348
UNSPSC
12352005
Hazard Statement
H315, H317, H319, H335
Target
Aurora Kinase; PDGFR; VEGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ABT-348.html
Purity
99.86
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(F)=C1)NC2=CC=C(C3=CSC4=C3C(N)=NC=C4C5=CN(CCO)N=C5)C=C2
Molecular Formula
C25H21FN6O2S
Molecular Weight
488.54
Precautions
H315, H317, H319, H335
References & Citations
[1]Yi-Chun Wang, et al. Abstract 858: Potent in vivo activity of the aurora kinase inhibitor ABT-348 in human acute myeloid leukemia and myelodysplastic syndrome xenograft models. Cancer Res (2012) 72 (8_Supplement) : 858.|[2]Glaser KB, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343 (3) :617-27.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Aurora A; Aurora B; Aurora C; PDGFRα; PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4

Alternative Products

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GTR19166331-01Ilorasertib
GTR19205592Ilorasertib hydrochloride
A20982-200Ilorasertib 200mg
A20982-25Ilorasertib 25mg
A20982-5Ilorasertib 5mg
A20982-1Ilorasertib 1mg
A20982-100Ilorasertib 100mg
A20982-50Ilorasertib 50mg
A20982-10Ilorasertib 10mg

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