Nalmefene

• Description:

  Nalmefene is a BBB-penetrable opioid receptor modulator. Nalmefene is an antagonist of MOR and DOR, and a partial agonist of KOR. Nalmefene has anti-inflammatory and neuroprotective activities. Nalmefene can be used in the research of reducing alcohol-dependent disorders[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H312, H332

• Target:

  Apoptosis; NF-κB; NO Synthase; Opioid Receptor; p38 MAPK; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/nalmefene.html

• Concentration:

  10mM

• Purity:

  99.94

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O[C@]12[C@@]34C5=C(C[C@@]2([H])N(CC6CC6)CC4)C=CC(O)=C5O[C@@]3([H])C(CC1)=C

• Molecular Formula:

  C21H25NO3

• Molecular Weight:

  339.43

• Precautions:

  H302, H312, H332

• References & Citations:

  [1]Wang DS, et al. Nalmefene: a long-acting opioid antagonist. Clinical applications in emergency medicine. J Emerg Med. 1998 May-Jun;16 (3) :471-5.|[2]Osborn MD, et al. In vivo characterization of the opioid antagonist nalmefene in mice. Life Sci. 2010 Apr 10;86 (15-16) :624-30.|[3]Montesinos J, et al. Nalmefene Prevents Alcohol-Induced Neuroinflammation and Alcohol Drinking Preference in Adolescent Female Mice: Role of TLR4. Alcohol Clin Exp Res. 2017 Jul;41 (7) :1257-1270.|[4]Koga M, et al. Nalmefene, an opioid receptor modulator, aggravates atherosclerotic plaque formation in apolipoprotein E knockout mice by enhancing oxidized low-density lipoprotein uptake in macrophages. Biochem Biophys Rep. 2024 Mar 23;38:101688.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [55096-26-9]