A-836339

• Description:

  A-836339 is a selective CB2 receptor agonist, with Ki values of 0.4 nM and 0.8 nM in humans and rats, respectively. A-836339 exhibits multiple effects such as analgesia, gastric protection, anti-inflammation, and antioxidant activity. A-836339 produces antinociceptive and analgesic activities by activating CB2 receptors in the dorsal root ganglia and spinal cord. A-836339 can also exert gastric protective effects through anti-inflammatory mechanisms (reducing TNF-α and IL-1β) and antioxidant mechanisms (enhancing the activities of CAT and SOD, and reducing H2O2) . Radioactively labeled A-836339 can serve as a CB2-specific radioligand for autoradiography and PET imaging. A-836339 can be used in research on inflammatory pain, neuropathic pain, gastric ulcers, cerebral ischemia, etc[1][2][3][4][5].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Cannabinoid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease; Others

• Assay Protocol:

  https://www.medchemexpress.com/A-836339.html

• Purity:

  99.84

• Solubility:

  DMSO : 12 mg/mL (ultrasonic; warming)

• Smiles:

  CC1=C (C) S/C (N1CCOC) =N\C (C2C (C) (C) C2 (C) C) =O

• Molecular Formula:

  C16H26N2O2S

• Molecular Weight:

  310.45

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  11

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  959746-77-1