E-Cadherin Polyclonal Antibody

• Background:

  Epithelial (E) - Cadherin (ECAD), also known as cell-CAM120/80 in the human, uvomorulin in the mouse, Arc-1 in the dog, and L-CAM in the chicken, is a member of the cadherin family of cell adhesion molecules. Cadherins are calcium-dependent transmembrane proteins, which bind to one another in a homophilic manner. On their cytoplasmic side, they associate with the three catenins, alpha, beta, and gamma (plakoglobin) . This association links the cadherin protein to the cytoskeleton. Without association with the catenins, the cadherins are non-adhesive. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult. E-Cadherin may also play a role in tumor development, as loss of E-Cadherin has been associated with tumor invasiveness. E-Cadherin is a classical cadherin molecule. Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium‑dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. E‑Cadherin contains five extracellular calcium-binding domains of approximately 110 amino acids each.

• Abbreviation:

  E-Cadherin

• UniProt:

  P12830

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant Human E-Cadherin protein expressed by E.coli

• Target:

  Arc 1; Arc 1; CADH1; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD 324; CD324; CD324 antigen; cdh1; CDHE; E-Cad/CTF3; E-cadherin; ECAD; Epithelial cadherin; epithelial calcium dependant adhesion protein; LCAM; Liver cell adhesion molecule; UVO; Uvomorulin; Arc-1; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CD 324; CD324 antigen; E-Cad/CTF3; epithelial calcium dependant adhesion protein; Liver cell adhesion molecule; CDH; Arc; CADH; CD antigen CD; Cleaved into: E-Cad/CTF; Cadherin; CAM 120/; Arc-1; CD324; CDHE; ECAD; LCAM; UVO; CDH1; E-Cadherin; CADH1; Cadherin-1; Uvomorulin; E-Cad; CTF2; CAM 120/80; Epithelial cadherin; CD antigen CD324; Cleaved into: E-Cad/CTF1; CTF3; CDH1

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Signal Transduction; Cancer; Developmental Biology; Tags & Cell Markers

• Purification:

  Antigen Affinity Purification

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:250-1:500

• Buffer:

  PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol, pH7.4

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  98 kDa

• Observed Molecular Weight:

  120 kDa

• Isotype:

  IgG