Pimavanserin

• Description:

  Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.

• Product Name Alternative:

  ACP-103

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/pimavanserin.html

• Purity:

  99.86

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CC(C)COC1=CC=C(CNC(N(CC2=CC=C(F)C=C2)C3CCN(C)CC3)=O)C=C1

• Molecular Formula:

  C25H34FN3O2

• Molecular Weight:

  427.55

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Vanover KE, et al. Pharmacological and behavioral profile of N- (4-fluorophenylmethyl) -N- (1-methylpiperidin-4-yl) -N'- (4- (2-methylpropyloxy) phenylmethyl) carbamide (2R,3R) -dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine (2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317 (2) :910-8.|[2]Vanover KE, et al. A 5-HT2A receptor inverse agonist, ACP-103, reduces tremor in a rat model and levodopa-induced dyskinesias in a monkey model. Pharmacol Biochem Behav. 2008 Oct;90 (4) :540-4.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  5-HT2 Receptor; α-1 microglobulin

• Citation 01:

  ACS Chem Neurosci. 2019 Nov 20;10 (11) :4476-4491. |bioRxiv. 2020 Feb.|Department Neuroscience. Virginia Commonwealth University. 2016 Oct.|Int J Clin Exp Med. 2019;12 (8) :10342-10349|Int J Neuropsychopharmacol. 2021 Sep 21;24 (9) :749-757.|J Med Chem. 2023 Jul 13;66 (13) :9057-9075.|Patent. US20200352950A1.|Proc Natl Acad Sci U S A. 2020 Oct 20;117 (42) :26438-26447.|Sci Rep. 2024 Jan 16;14 (1) :1396.|bioRxiv. 2023 Jul 31:2023.07.29.551106.|Food Chem Toxicol. 2023 Jun:176:113800.|Nat Commun. 2023 Dec 15;14 (1) :8221.

• CAS Number:

  [706779-91-1]