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AAPH

CAT: 0804-HY-Y0525-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-Y0525-01Size:1 g
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Description
AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has an effect of radical generation. AAPH induces oxidative stress and erythrocyte hemolysis[1]. AAPH decomposes at 37°C to generate an alkyl radical, is used as an initiator. In the presence of oxygen, these alkyl radicals will be converted to peroxyl radicals that can cause lipid peroxidation and loss of erythrocyte membrane integrity, which could ultimately lead to hemolysis[1][2][3][4].
CAS Number
2997-92-4
Product Name Alternative
2,2'-Azodiisobutyramidine dihydrochloride
UNSPSC
12352211
Hazard Statement
H251, H302, H317, H319, H410
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/aaph.html
Purity
98.0
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
CC(/N=N/C(C)(C)C(N)=N)(C)C(N)=N.[H]Cl.[H]Cl
Molecular Formula
C8H20Cl2N6
Molecular Weight
271.19
Precautions
H251, H302, H317, H319, H410
References & Citations
[1]Sean M. Culbertson, et al. Unsymmetrical Azo Initiators Increase Efficiency of Radical Generation in Aqueous Dispersions, Liposomal Membranes, and Lipoproteins. J. Am. Chem. Soc. 2000, 122, 17, 4032–4038.|[2]Liao W, et al. Intracellular antioxidant detoxifying effects of diosmetin on 2,2-azobis (2-amidinopropane) dihydrochloride (AAPH) -induced oxidative stress through inhibition of reactive oxygen species generation. J Agric Food Chem. 2014 Aug 27;62 (34) :8648-54.|[3]Peyrat-Maillard M N, et al. Antioxidant activity of phenolic compounds in 2, 2′‐azobis (2‐amidinopropane) dihydrochloride (AAPH) ‐induced oxidation: Synergistic and antagonistic effects[J]. Journal of the American Oil Chemists' Society, 2003, 80 (10) : 1007.|[4]Hosseinian FS, et al. AAPH-mediated antioxidant reactions of secoisolariciresinol and SDG. Org Biomol Chem. 2007 Feb 21;5 (4) :644-54.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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