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AS1269574

CAT: 0804-HY-107535-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107535-01Size:5 mg
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Description
AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes[1][2].
CAS Number
330981-72-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GPR119; TRP Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/as1269574.html
Purity
99.84
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
OCCNC1=NC(C2=CC=C(Br)C=C2)=NC(C)=C1
Molecular Formula
C13H14BrN3O
Molecular Weight
308.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Yoshida S, et al. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochem Biophys Res Commun. 2010;400 (3) :437-441.|[2]Chepurny OG, et al. GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion. Mol Endocrinol. 2016;30 (6) :614-629.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPA1

Alternative Products

CatalogName
T21623-01AS1269574
217392GPR119 Agonist, AS1269574 (G-Protein Coupled Receptor 119 Agonist, 2- ((2- (4-Bromophenyl) -6-methylpyrimidin-4-yl) amino) ethanol, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist)

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