Fingolimod-d4 (hydrochloride)

Fingolimod-d4 (hydrochloride)

• CAS Number: 1346604-90-7
• UNSPSC Description: Fingolimod-d4 (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1].
• Target Antigen: LPL Receptor; PAK
• Type: Isotope-Labeled Compounds
• Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton;GPCR/G Protein
• Field of Research: Cancer; Inflammation/Immunology
• Purity: 99.0
• Solubility: 10 mM in DMSO
• Smiles: OC([2H])([2H])C(C([2H])([2H])O)(N)CCC1=CC=C(C=C1)CCCCCCCC.Cl[H]
• Molecular Weight: 347.96
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Szepanowski F, et al. Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling. J Neuroinflammation. 2016 Jun 10;13(1):143.|[3]Shirakabe K, et al. Modification of lymphocyte migration to Peyer's patches by inhibition of sphingosine-1-phosphate lyase ameliorates murine colitis. J Gastroenterol Hepatol. 2018 Jan 15.|[4]Rolin J, et al. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol Immunother. 2010, 59(4), 575-586.|[5]Airas L, et al. In vivo PET imaging demonstrates diminished microglial activation after fingolimod treatment in an animal model of multiple sclerosis. J Nucl Med. 2015 Feb;56(2):305-10.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported