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Pantoprazole

CAT: 0804-HY-17507-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17507-01Size:100 mg
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Description
Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin[4].
CAS Number
102625-70-7
Product Name Alternative
BY1023; SKF96022
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Apoptosis; Autophagy; Bacterial; Proton Pump
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pantoprazole.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=NC2=CC=C(OC(F)F)C=C2N1)CC3=NC=CC(OC)=C3OC
Molecular Formula
C16H15F2N3O4S
Molecular Weight
383.37
Precautions
H315, H319, H320
References & Citations
[1]Krupa J Patel, et al. Use of the proton pump inhibitor pantoprazole to modify the distribution and activity of doxorubicin: a potential strategy to improve the therapy of solid tumors. Clin Cancer Res. 2013 Dec 15;19 (24) :6766-76.|[2]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35 (1) :1322-1330.|[3]W Beil, et al. Pantoprazole: a novel H+/K (+) -ATPase inhibitor with an improved pH stability. Eur J Pharmacol. 1992 Aug 6;218 (2-3) :265-71.|[4]K Takeuchi, et al. Effects of pantoprazole, a novel H+/K+-ATPase inhibitor, on duodenal ulcerogenic and healing responses in rats: a comparative study with omeprazole and lansoprazole. J Gastroenterol Hepatol. 1999 Mar;14 (3) :251-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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