Ku-80 rabbit pAb

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Background

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V (D) J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V (D) J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

Description

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V (D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V (D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],

UniProt

P13010

Swiss Prot

P13010

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from human Ku-80

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; WB

Concentration

1 mg/ml

Dilution

IHC-p 1:50-200, WB 1:500-2000

Molecular Weight

82kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

82kD

Fragment

IgG

Subcellular Location

Nucleus . Nucleus, nucleolus . Chromosome .

Other Product Names

X-ray repair cross-complementing protein 5 (EC 3.6.4.-;86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; Ku80; Ku86; Lupus Ku autoantigen protein p86; Nuclear factor IV; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) )

Gene ID (Human)

7520

UniProtKB · P13010

DNA repair protein Ku80

XRCC5_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P13010
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: XRCC5
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 4.2.99.18, 5.6.2.4
Processing: —
Secondary accessions: A8K3X5, Q0Z7V0, Q4VBQ5, Q53HH7, Q7M4N0, Q9UCQ0, Q9UCQ1

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationADP-ribosylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingHelicaseHydrolaseIsomeraseLyase

Ligand

ATP-bindingNucleotide-binding

Cellular component

ChromosomeNucleus

Biological process

DNA damageDNA recombinationDNA repairHost-virus interactionImmunityInnate immunityRibosome biogenesisTranscriptionTranscription regulation

Disease

Systemic lupus erythematosus

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APRab13157-01	Ku-80 Rabbit Polyclonal Antibody
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E53P04698	Ku-80 T714 Rabbit Polyclonal Antibody
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APRab04928-01	Ku-80 (phospho Thr714) Rabbit Polyclonal Antibody
GTR18052761-01	Ku-80 (phospho Thr714) rabbit pAb Antibody
PA86243HU-01	Rabbit Anti-Human Ku-80 Polyclonal Antibody