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TFGF-18

CAT: 0804-HY-171031Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-171031Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TFGF-18 is a GSK-3β inhibitor (IC50: 0.59 μM) . TFGF-18 inhibits LPS-induced microglia activation and proinflammatory mediators release via inhibiting GSK-3β and downstream p65/NF-κB signaling. TFGF-18 inhibits neuronal apoptosis and oxidative stress, inhibits expressions of Bax, caspase3 and cleaved-caspase3 and increases the expression of Bcl-2. TFGF-18 has neuroprotection effect, inhibit neuroinflammation and attenuates cognitive impairment[1][2].
CAS Number
2222662-20-4
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; GSK-3; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tfgf-18.html
Smiles
COC1=C(C(C=C(C2=CC(OC)=C(C=C2)OC)O3)=O)C3=CC(OC)=C1[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(N[C@@H](C)C(F)(F)F)=O
Molecular Formula
C28H30F3NO11
Molecular Weight
613.53
References & Citations
[1]Xu M, et al. Anti-Neuroinflammatory Effects of a Semi-Synthetic Isoorientin-Based Glycogen Synthase Kinase-3β Inhibitor in Lipopolysaccharide-Activated Microglial Cells. ACS Chem Neurosci. 2022 Jan 5;13 (1) :43-52.|[2]Zhao Y, et al. Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway. Exp Neurol. 2024 Oct;380:114881.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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