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KRM-III

CAT: 0804-HY-136427-01Size: 5 mgDry Ice: NoHazardous: No
CAT#: HY-136427-01Size: 5 mg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of ~5 μM. Anti-inflammatory activity[1].
CAS Number
[79220-94-3]
UNSPSC
12352005
Hazard Statement
H319
Target
Nuclear Factor of activated T Cells (NFAT)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/krm-iii.html
Concentration
10mM
Purity
98.08
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
S=C1NC(C2=CC=CC=C2)=CN1C3=CC=CC=C3
Molecular Formula
C15H12N2S
Molecular Weight
252.33
Precautions
H319
References & Citations
[1]Eun Joo Jung, et al. Oral administration of 1,4-aryl-2-mercaptoimidazole inhibits T-cell proliferation and reduces clinical severity in the murine experimental autoimmune encephalomyelitis model. J Pharmacol Exp Ther. 2009 Dec;331 (3) :1005-13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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