KRM-III

• UNSPSC Description:

  KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of ~5 μM. Anti-inflammatory activity[1].

• Target Antigen:

  Nuclear Factor of activated T Cells (NFAT)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/krm-iii.html

• Smiles:

  S=C1NC(C2=CC=CC=C2)=CN1C3=CC=CC=C3

• Molecular Weight:

  252.33

• References & Citations:

  [1]Eun Joo Jung, et al. Oral administration of 1,4-aryl-2-mercaptoimidazole inhibits T-cell proliferation and reduces clinical severity in the murine experimental autoimmune encephalomyelitis model. J Pharmacol Exp Ther. 2009 Dec;331(3):1005-13.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  79220-94-3