Droxidopa (Standard)

• Description :

  Droxidopa (Standard) is the analytical standard of Droxidopa. This product is intended for research and analytical applications. Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder) [1][2][3][4].

• Product Name Alternative :

  L-DOPS (Standard) ; DOPS (Standard) ; SM5688 (Standard)

• UNSPSC :

  12352005

• Target :

  Adrenergic Receptor; Reference Standards

• Type :

  Reference Standards

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling; Others

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/droxidopa-standard.html

• Smiles :

  OC1=C(O)C=CC([C@@H](O)[C@@H](C(O)=O)N)=C1

• Molecular Formula :

  C9H11NO5

• Molecular Weight :

  213.19

• References & Citations :

  [1]Horacio Kaufmann, et al. Droxidopa for neurogenic orthostatic hypotension. Neurology, 2014; 83 (4) .|[2]Dela Peña I, et al. Droxidopa alters dopamine neuron and prefrontal cortex activity and improves attention-deficit/hyperactivity disorder-like behaviors in rats. Eur J Pharmacol. 2021 Feb 5;892:173826.|[3]Cao LF, et al. Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson's Disease. Neural Plast. 2016;2016:6383240. |[4]Kaufmann H. L-dihydroxyphenylserine (Droxidopa) : a new therapy for neurogenic orthostatic hypotension: the US experience. Clin Auton Res. 2008 Mar;18 Suppl 1:19-24.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [23651-95-8]