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Lobetyol

CAT: 0804-HY-117652-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117652-01Size:1 mg
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Description
Lobetyol is a natural compound that can be isolated from Lobelia chinensis. Lobetyol induces apoptosis and cell cycle arrest in MKN45 cells. Lobetyol shows anti-virus, anti-inflammation and anti-tumor activity[1][2]. Lobetyol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
136171-87-4
Product Name Alternative
Mutagenic Impurity of Tenofovir Disoproxil; Tenofovir Impurity 2, Methyl (2E,4E,6Z)-decatrienoate
UNSPSC
12352211
Target
Apoptosis; Bcl-2 Family; MDM-2/p53
Type
Natural Products
Related Pathways
Apoptosis
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lobetyol.html
Solubility
10 mM in DMSO
Smiles
C/C=C/C#CC#CC(O)C(O)/C=C/CCCO
Molecular Formula
C14H18O3
Molecular Weight
234.29
References & Citations
[1]Shen J, et al. Lobetyol activate MAPK pathways associated with G1/S cell cycle arrest and apoptosis in MKN45 cells in vitro and in vivo. Biomed Pharmacother. 2016 Jul;81:120-127.|[2]Xie Q, et al. The in vitro/in vivo metabolic pathways analysis of lobetyol, lobetyolin, and lobetyolinin, three polyacetylenes from Codonopsis Radix, by UHPLC-Q/TOF-MS and UHPLC-MS/MS. J Pharm Biomed Anal. 2023 Jan 20;223:115140.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2

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